HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-591448
DOI to cite this document:: 10.5283/epub.59144

Albert, Veruschka ; Bruss, Christina ; Tümen, Deniz ; Piendl, Gerhard ; Weber, Florian

; Dahl, Edgar ; Seitz, Stephan ; Ortmann, Olaf

; Wege, Anja K.

; Brockhoff, Gero

License: Creative Commons Attribution 4.0
PDF - Published Version
(18MB)

Date of publication of this fulltext: 11 Sep 2024 08:15

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

The impact of the HER4 receptor on the growth and treatment of estrogen receptor-positive breast cancer is widely uncertain. Using CRISPR/Cas9 technology, we generated stable HER4 knockout variants derived from the HER4-positive MCF-7, T-47D, and ZR-75-1 breast cancer cell lines. We investigated tumor cell proliferation as well as the cellular and molecular mechanisms of ...