Synthetic soldiers: Turning T cells into immortal warriors

URN to cite this document:: urn:nbn:de:bvb:355-epub-591655
DOI to cite this document:: 10.5283/epub.59165

Restifo, Nicholas P. ; Gattinoni, Luca

License: Creative Commons Attribution Non-commercial Share Alike 4.0
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Date of publication of this fulltext: 12 Sep 2024 15:52

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Abstract

The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?

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