Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients

URN to cite this document:: urn:nbn:de:bvb:355-epub-591706
DOI to cite this document:: 10.5283/epub.59170

Schmidtner, Niklas ; Utrata, Alexander ; Mester, Patricia ; Schmid, Stephan

; Müller, Martina ; Pavel, Vlad

; Buechler, Christa

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Sep 2024 12:16

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Abstract

Infectious diseases are associated with low iron levels and the induction of hepcidin, the primary protein regulating cellular iron export. Bone morphogenetic protein 6 (BMP6), a key regulator of hepcidin expression, has not yet been analyzed in the plasma of patients with systemic inflammatory response syndrome (SIRS) or sepsis. An analysis of 38 SIRS, 39 sepsis, and 78 septic shock patients ...