Since the initial identification of oncogenic Wnt in mice and Drosophila, the Wnt signaling
pathway has been subjected to thorough and extensive investigation. Persistent activation of Wnt
signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell
senescence, cell death, differentiation, and metastasis. Here we review the principal signaling
mechanisms and the regulatory influence of pathway-intrinsic and extrinsic kinases on cancer
progression. Additionally, we underscore the divergences and intricate interplays of the canonical
and non-canonical Wnt signaling pathways and their critical influence in cancer pathophysiology,
exhibiting both growth-promoting and growth-suppressing roles across diverse cancer types.