Unraveling Cancer’s Wnt Signaling: Dynamic Control through Protein Kinase Regulation

URN to cite this document:: urn:nbn:de:bvb:355-epub-591734
DOI to cite this document:: 10.5283/epub.59173

Tümen, Deniz ; Heumann, Philipp ; Huber, Juliette ; Hahn, Nele ; Macek, Celina ; Ernst, Martha ; Kandulski, Arne ; Kunst, Claudia ; Gülow, Karsten

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Sep 2024 13:14

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Abstract

Since the initial identification of oncogenic Wnt in mice and Drosophila, the Wnt signaling pathway has been subjected to thorough and extensive investigation. Persistent activation of Wnt signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell senescence, cell death, differentiation, and metastasis. Here we review the principal signaling mechanisms ...