Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies

URN to cite this document:: urn:nbn:de:bvb:355-epub-592272
DOI to cite this document:: 10.5283/epub.59227

Ousingsawat, Jiraporn

; Schreiber, Rainer

; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Sep 2024 08:26

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Abstract

Anoctamin 6 (ANO6, TMEM16F) is a phospholipid (PL) scramblase that moves PLs between both plasma membrane (PM) leaflets and operates as an ion channel. It plays a role in development and is essential for hemostasis, bone mineralization and immune defense. However, ANO6 has also been shown to regulate cellular Ca2+ signaling and PM compartments, thereby controlling the expression of ion channels ...