Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-594347
DOI to cite this document:: 10.5283/epub.59434

Ehrnsperger, Marianne ; Taheri, Shahed ; Pann, Patrick ; Schilling, Arndt F. ; Grässel, Susanne

License: Creative Commons Attribution 4.0
PDF - Published Version
(4MB)

Date of publication of this fulltext: 28 Oct 2024 12:49

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Bisphosphonates (BP) are considered a treatment option for osteoarthritis (OA) due to reduction of OA-induced microtrauma in the bone marrow, stabilization of subchondral bone (SB) layer and pain reduction. The effects of high-dose alendronate (ALN) treatment on SB and articular cartilage after destabilization of the medial meniscus (DMM) or Sham surgery of male C57Bl/6J mice were analyzed. We ...