Electrochemical Homo‐ and Crossannulation of Alkynes and Nitriles for the Regio‐ and Chemoselective Synthesis of 3,6‐Diarylpyridines

URN to cite this document:: urn:nbn:de:bvb:355-epub-594547
DOI to cite this document:: 10.5283/epub.59454

Ghosh, Mangish ; Mandal, Tirtha ; Lepori, Mattia ; Barham, Joshua P.

; Rehbein, Julia

; Reiser, Oliver

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Oct 2024 12:55

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Abstract

We disclose a mediated electrochemical [2+2+2] annulation of alkynes with nitriles, forming substituted pyridines in a single step from low-cost, readily available starting materials. The combination of electrochemistry and a triarylamine redox mediator obviates the requirements of transition metals and additional oxidants. Besides the formation of diarylpyridine moieties via the homocoupling of ...