Proteolytic shedding of CD46 from human hepatocytes indicates liver stress

URN to cite this document:: urn:nbn:de:bvb:355-epub-597495
DOI to cite this document:: 10.5283/epub.59749

Kupke, Paul

; Yang Zhou, Jordi ; Glehr, Gunther

; Riquelme, Paloma

; Scheibert, Lena ; Adenugba, Akinbami ; Schlitt, Hans J.

; Geissler, Edward K.

; Werner, Jens M.

; Hutchinson, James A.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Dec 2024 08:46

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Abstract

Background Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46 (sCD46) levels in blood were recently identified as an accurate biomarker of hepatic steatosis. Here, we explore the diagnostic utility of sCD46 in other liver diseases. Methods We ...