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Merging New and Old Concepts: Tandem Oxidative Radical‐Polar Crossover Ritter Amidation via Multicomponent Photo‐ and Electrochemical Processes
Lepori, Mattia
, Dey, Indrasish
, Pratley, Cassie
und Barham, Joshua P.
(2024)
Merging New and Old Concepts: Tandem Oxidative Radical‐Polar Crossover Ritter Amidation via Multicomponent Photo‐ and Electrochemical Processes.
European Journal of Organic Chemistry, e202400840.
Veröffentlichungsdatum dieses Volltextes: 11 Dez 2024 05:49
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.59763
Zusammenfassung
Nitrogen-containing drug molecules and pharmaceuticals are ubiquitous, rendering the construction of C−N bonds a crucial target in methodology development. The Ritter reaction is a well-established method for accessing C−N bonds by generating amide functionality through the reaction of carbocations and nitriles. Since its discovery back in 1948, the Ritter reaction has progressively advanced ...
Nitrogen-containing drug molecules and pharmaceuticals are ubiquitous, rendering the construction of C−N bonds a crucial target in methodology development. The Ritter reaction is a well-established method for accessing C−N bonds by generating amide functionality through the reaction of carbocations and nitriles. Since its discovery back in 1948, the Ritter reaction has progressively advanced towards milder and more sustainable conditions for carbocation generation. In this regard, notable contributions have been made by means of single electron transfer (SET) chemistry. Nowadays, photo- and electrochemistry are established methods of choice for the generation of reactive radical intermediates and their subsequent oxidation via radical-polar crossover (RPC) mechanism. We review recent examples of tandem RPC and Ritter-type protocols, demonstrating how photo- and electrochemical energies have been effectively harvested to expand the precursor pool for the Ritter reaction as well as reimagining the process with novel mechanisms and additives.
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| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | European Journal of Organic Chemistry | ||||
| Verlag: | Wiley | ||||
|---|---|---|---|---|---|
| Seitenbereich: | e202400840 | ||||
| Datum | 18 September 2024 | ||||
| Institutionen | Chemie und Pharmazie > Institut für Organische Chemie | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | Amination · Radical polar crossover · Single electron transfer · Ritter reaction · Amidation | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-597635 | ||||
| Dokumenten-ID | 59763 |
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