Kroiss, Matthias 
; Fassnacht, Martin ; Allolio, Bruno ; Rosenwald, Andreas ; Schmitz, Gerd ; Deutschbein, Timo ; Ronchi, Cristina L. ; Bala, Margarita ; Weigand, Isabel ; Kendl, Sabine ; Gehl, Annemarie ; Gardill, Felix ; Eckhardt, Carolin ; Matysik, Silke ; Wiemer, Laura ; Schirbel, Andreas ; Sbiera, Iuliu ; Liebisch, Gerhard ; Leich, Ellen ; Sbiera, Silviu
; Fassnacht, Martin ; Allolio, Bruno ; Rosenwald, Andreas ; Schmitz, Gerd ; Deutschbein, Timo ; Ronchi, Cristina L. ; Bala, Margarita ; Weigand, Isabel ; Kendl, Sabine ; Gehl, Annemarie ; Gardill, Felix ; Eckhardt, Carolin ; Matysik, Silke ; Wiemer, Laura ; Schirbel, Andreas ; Sbiera, Iuliu ; Liebisch, Gerhard ; Leich, Ellen ; Sbiera, Silviu 
Abstract
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and counteracts tumor growth and steroid hormone production. Despite serious adverse effects, mitotane has been clinically used for decades. Elucidation of its unknown molecular mechanism of action seems essential to develop better ACC ...
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