; Baurecht, Hansjörg
; Margaritte-Jeannin, Patricia ; Sääf, Annika ; Kerkhof, Marjan ; Ege, Markus
; Baltic, Svetlana ; Matheson, Melanie C.
; Li, Jin ; Michel, Sven ; Ang, Wei Q. ; McArdle, Wendy ; Arnold, Andreas ; Homuth, Georg ; Demenais, Florence
; Bouzigon, Emmanuelle ; Söderhäll, Cilla ; Pershagen, Göran ; de Jongste, Johan C. ; Postma, Dirkje S. ; Braun-Fahrländer, Charlotte ; Horak, Elisabeth ; Ogorodova, Ludmila M.
; Puzyrev, Valery P.
; Bragina, Elena Yu
; Hudson, Thomas J. ; Morin, Charles ; Duffy, David L.
; Marks, Guy B. ; Robertson, Colin F. ; Montgomery, Grant W.
; Musk, Bill ; Thompson, Philip J. ; Martin, Nicholas G. ; James, Alan ; Sleiman, Patrick ; Toskala, Elina ; Rodriguez, Elke ; Fölster-Holst, Regina ; Franke, Andre
; Lieb, Wolfgang ; Gieger, Christian
; Heinzmann, Andrea ; Rietschel, Ernst ; Keil, Thomas ; Cichon, Sven
; Nöthen, Markus M. ; Pennell, Craig E.
; Sly, Peter D.
; Schmidt, Carsten O. ; Matanovic, Anja ; Schneider, Valentin ; Heinig, Matthias
; Hübner, Norbert ; Holt, Patrick G.
; Lau, Susanne
; Kabesch, Michael ; Weidinger, Stefan
; Hakonarson, Hakon ; Ferreira, Manuel A. R. ; Laprise, Catherine ; Freidin, Maxim B.
; Genuneit, Jon
; Koppelman, Gerard H. ; Melén, Erik ; Dizier, Marie- Hélène
; Henderson, A John ; Lee, Young Ae | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Nature Communications | ||||
| Publisher: | NATURE PUBLISHING GROUP | ||||
| Place of Publication: | LONDON | ||||
| Volume: | 6 | ||||
| Number of Issue or Book Chapter: | 1 | ||||
| Date: | 2015 | ||||
| Institutions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | JUVENILE MYOCLONIC EPILEPSY; FOOD ALLERGY; FILAGGRIN MUTATIONS; BIRTH COHORT; HAY-FEVER; GENOMEWIDE ASSOCIATION; CHROMOSOME 11Q13; CHILDHOOD ASTHMA; DERMATITIS; RISK; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 59959 |

Abstract
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined ...

Abstract
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P = 2.1 x 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P = 5.3 x 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
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