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Heterozygous modulation of TGF-β signaling does not influence Müller glia cell reactivity or proliferation following NMDA-induced damage

Kugler, Martina ; Schlecht, Anja ; Fuchshofer, Rudolf ; Kleiter, Ingo ; Aigner, Ludwig ; Tamm, Ernst R. ; Braunger, Barbara M.



Zusammenfassung

The stimulation of progenitor or stem cells proliferation in the retina could be a therapeutic avenue for the treatment of various ocular neurodegenerative disorders. Muller glia cells have been discussed to represent a progenitor cell population in the adult retina. In the brain, TGF-beta signaling regulates the fate of stem cells; however, its role in the vertebrate retina is unclear. We ...

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