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T cell responses in early-stage melanoma patients occur frequently and are not associated with humoral response

Pfirschke, Christina ; Gebhardt, Christoffer ; Zörnig, Inka ; Pritsch, Maria ; Eichmüller, Stefan B. ; Jäger, Dirk ; Enk, Alexander ; Beckhove, Philipp



Abstract

Endogenous tumor-specific T cells are detectable in patients with different tumor types including malignant melanoma (MM). They can control tumor growth, have impact on patient survival and correlate with improved clinical response to immune checkpoint therapy. Thus, they may represent a potent biomarker for respective treatment decisions. So far, major target antigens of endogenous MM-reactive T ...

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