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Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis

Alpini, Gianfranco ; Schulze, Kornelius ; Weismüller, Tobias J. ; Bubenheim, Michael ; Huebener, Peter ; Zenouzi, Roman ; Lenzen, Henrike ; Rupp, Christian ; Gotthardt, Daniel ; de Leuw, Philipp ; Teufel, Andreas ; Zimmer, Vincent ; Reiter, Florian P. ; Rust, Christian ; Tharun, Lars ; Quaas, Alexander ; Weidemann, Sören A. ; Lammert, Frank ; Sarrazin, Christoph ; Manns, Michael P. ; Lohse, Ansgar W. ; Schramm, Christoph



Abstract

Background & Aims Current guidelines recommend immunosuppressive treatment (IT) in patients with primary sclerosing cholangitis (PSC) and elevated aminotransferase levels more than five times the upper limit of normal and elevated serum IgG-levels above twice the upper limit of normal. Since there is no evidence to support this recommendation, we aimed to assess the criteria that guided ...

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