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Hurdles in therapy with regulatory T cells

Trzonkowski, Piotr ; Bacchetta, Rosa ; Battaglia, Manuela ; Berglund, David ; Bohnenkamp, Hermann Richard ; ten Brinke, Anja ; Bushell, Andrew ; Cools, Nathalie ; Geissler, Edward K. ; Gregori, Silvia ; Marieke van Ham, S. ; Hilkens, Catharien ; Hutchinson, James A. ; Lombardi, Giovanna ; Madrigal, J. Alejandro ; Marek-Trzonkowska, Natalia ; Martinez-Caceres, Eva M. ; Roncarolo, Maria Grazia ; Sanchez-Ramon, Silvia ; Saudemont, Aurore ; Sawitzki, Birgit



Abstract

Improper activation of the immune system contributes to a variety of clinical conditions, including autoimmune and allergic diseases as well as solid organ and bone marrow transplantation. One approach to counteract this activation is through adoptive therapy with regulatory T cells (T-regs). Efforts to manufacture these cells have led to good maunfacturing practice-compliant protocols, and T-reg ...

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