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Sensing Cardiac Electrical Activity With a Cardiac Myocyte–Targeted Optogenetic Voltage Indicator

Chang Liao, Mei-Ling ; de Boer, Teun P. ; Mutoh, Hiroki ; Raad, Nour ; Richter, Claudia ; Wagner, Eva ; Downie, Bryan R. ; Unsöld, Bernhard ; Arooj, Iqra ; Streckfuss-Bömeke, Katrin ; Döker, Stephan ; Luther, Stefan ; Guan, Kaomei ; Wagner, Stefan ; Lehnart, Stephan E. ; Maier, Lars S. ; Stühmer, Walter ; Wettwer, Erich ; van Veen, Toon ; Morlock, Michael M. ; Knöpfel, Thomas ; Zimmermann, Wolfram-Hubertus



Abstract

Rationale: Monitoring and controlling cardiac myocyte activity with optogenetic tools offer exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac excitation from the cellular to the whole heart level. Objective: To test the hypothesis that ...

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