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Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin – A multicenter study

Karl, Alexander ; Buchner, Alexander ; Tympner, Christiane ; Kirchner, Thomas ; Ganswindt, Ute ; Belka, Claus ; Ganzer, Roman ; Wieland, Wolf ; Eder, Fabian ; Hofstädter, Ferdinand ; Schilling, David ; Sievert, Karl-Dietrich ; Stenzl, Arnulf ; Scharpf, Marcus ; Fend, Falko ; vom Dorp, Frank ; Rübben, Herbert ; Schmid, Kurt Werner ; Porres-Knoblauch, Daniel ; Heidenreich, Axel ; Hangarter, Birgit ; Knüchel-Clarke, Ruth ; Rogenhofer, Michael ; Wullich, Bernd ; Hartmann, Arndt ; Comploj, Evi ; Pycha, Armin ; Hanspeter, Esther ; Pehrke, Dirk ; Sauter, Guido ; Graefen, Markus ; Gratzke, Christian ; Stief, Christian ; Wiegel, Thomas ; Haese, Alexander



Abstract

Background and purpose: Positive surgical margins (PSM) after radical prostatectomy have been shown to be associated with impaired outcome. In pT3pN0 patients with PSM either immediate radiotherapy or clinical and biological monitoring followed by salvage radiotherapy is recommended by the latest guidelines of the European Association of Urology. Materials and methods: A retrospective, ...

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