Singh, Pratibha ; Dejager, Lien ; Amand, Mathieu ; Theatre, Emilie ; Vandereyken, Maud 
; Zurashvili, Tinatin ; Singh, Maneesh ; Mack, Matthias ; Timmermans, Steven ; Musumeci, Lucia ; Dejardin, Emmanuel ; Mustelin, Tomas ; Van Ginderachter, Jo A. ; Moutschen, Michel ; Oury, Cécile ; Libert, Claude ; Rahmouni, Souad
; Zurashvili, Tinatin ; Singh, Maneesh ; Mack, Matthias ; Timmermans, Steven ; Musumeci, Lucia ; Dejardin, Emmanuel ; Mustelin, Tomas ; Van Ginderachter, Jo A. ; Moutschen, Michel ; Oury, Cécile ; Libert, Claude ; Rahmouni, Souad 
Abstract
DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological function. We report that DUSP3 is strongly expressed in human and mouse monocytes and macrophages, and that its deficiency in mice promotes tolerance to LPS-induced endotoxin shock and to polymicrobial septic shock after cecal ligation and puncture. By using adoptive transfer experiments, we demonstrate that ...
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