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Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75

Krumbholz, Markus ; Hofstadt-van Oy, Ulrich ; Angstwurm, Klemens ; Kleiter, Ingo ; Jarius, Sven ; Paul, Friedemann ; Aktas, Orhan ; Buchholz, Grete ; Kern, Peter ; Straube, Andreas ; Kümpfel, Tania



Abstract

Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients > 75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and ...

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