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Metabolomic tissue signature in human non‐alcoholic fatty liver disease identifies protective candidate metabolites

von Schönfels, Witigo ; Patsenker, Eleonora ; Fahrner, René ; Itzel, Timo ; Hinrichsen, Holger ; Brosch, Mario ; Erhart, Wiebke ; Gruodyte, Auste ; Vollnberg, Bernd ; Richter, Klaus ; Landrock, Andreas ; Schreiber, Stefan ; Brückner, Stephan ; Beldi, Guido ; Sipos, Bence ; Becker, Thomas ; Röcken, Christoph ; Teufel, Andreas ; Stickel, Felix ; Schafmayer, Clemens ; Hampe, Jochen



Abstract

BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries, yet its pathophysiology is incompletely understood. Small-molecule metabolite screens may offer new insights into disease mechanisms and reveal new treatment targets. MethodsDiscovery (N=33) and replication (N=66) of liver biopsies spanning the range from normal liver ...

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