Abstract
This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)(2)Cl-2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards ...
Abstract
This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)(2)Cl-2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)(2)Cl-2 is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)(2)Cl-2 may have a different antitumour specificity from that of cisplatin.
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