Abstract
The group of acquired myasthenic syndromes can be divided into the postsynaptic myasthenias (MG) and the presynaptic Lambert-Eaton syndrome (LEMS). By improvement of diagnostic procedures (receptor-auto-antibody testing, electrophysiology, imaging, pharmacological testing) it is possible to refer the specific diseases to pathophysiologically defined subgroups. This enables a better and more ...
Abstract
The group of acquired myasthenic syndromes can be divided into the postsynaptic myasthenias (MG) and the presynaptic Lambert-Eaton syndrome (LEMS). By improvement of diagnostic procedures (receptor-auto-antibody testing, electrophysiology, imaging, pharmacological testing) it is possible to refer the specific diseases to pathophysiologically defined subgroups. This enables a better and more specific therapy, e.g., indication for thymectomy or no thymectomy, different or more specific use of cholinesterase inhibitors for symptomatic treatment. Having more selective diagnostic as a consequence of the better pathophysiological understanding of the underlying processes at the neuromuscular synapsis, it is possible to use therapies more selectively, to avoid medical malpractice and to provide a better satisfaction for the patient.
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