Friedmann Angeli, Jose Pedro ; Schneider, Manuela ; Proneth, Bettina ; Tyurina, Yulia Y. ; Tyurin, Vladimir A. 
; Hammond, Victoria J. ; Herbach, Nadja ; Aichler, Michaela ; Walch, Axel ; Eggenhofer, Elke ; Basavarajappa, Devaraj ; Rådmark, Olof ; Kobayashi, Sho ; Seibt, Tobias ; Beck, Heike ; Neff, Frauke ; Esposito, Irene ; Wanke, Rüdiger ; Förster, Heidi ; Yefremova, Olena ; Heinrichmeyer, Marc ; Bornkamm, Georg W. ; Geissler, Edward K. ; Thomas, Stephen B. ; Stockwell, Brent R. ; O’Donnell, Valerie B. ; Kagan, Valerian E. ; Schick, Joel A. ; Conrad, Marcus
; Hammond, Victoria J. ; Herbach, Nadja ; Aichler, Michaela ; Walch, Axel ; Eggenhofer, Elke ; Basavarajappa, Devaraj ; Rådmark, Olof ; Kobayashi, Sho ; Seibt, Tobias ; Beck, Heike ; Neff, Frauke ; Esposito, Irene ; Wanke, Rüdiger ; Förster, Heidi ; Yefremova, Olena ; Heinrichmeyer, Marc ; Bornkamm, Georg W. ; Geissler, Edward K. ; Thomas, Stephen B. ; Stockwell, Brent R. ; O’Donnell, Valerie B. ; Kagan, Valerian E. ; Schick, Joel A. ; Conrad, Marcus 
Abstract
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-transformed cells and tissues is unexplored and remains enigmatic. Here, we provide direct genetic evidence that the knockout of glutathione peroxidase 4 (Gpx4) causes cell death in a pathologically relevant form of ...
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