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FHL2 expression and variants in hypertrophic cardiomyopathy

Friedrich, Felix W. ; Reischmann, Silke ; Schwalm, Aileen ; Unger, Andreas ; Ramanujam, Deepak ; Münch, Julia ; Müller, Oliver J. ; Hengstenberg, Christian ; Galve, Enrique ; Charron, Philippe ; Linke, Wolfgang A. ; Engelhardt, Stefan ; Patten, Monica ; Richard, Pascale ; van der Velden, Jolanda ; Eschenhagen, Thomas ; Isnard, Richard ; Carrier, Lucie



Abstract

Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis and is mainly caused by mutations in genes ...

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