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Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis

Hannan, Thomas J. ; Roberts, Pacita L. ; Riehl, Terrence E. ; van der Post, Sjoerd ; Binkley, Jana M. ; Schwartz, Drew J. ; Miyoshi, Hiroyuki ; Mack, Matthias ; Schwendener, Reto A. ; Hooton, Thomas M. ; Stappenbeck, Thaddeus S. ; Hansson, Gunnar C. ; Stenson, William F. ; Colonna, Marco ; Stapleton, Ann E. ; Hultgren, Scott J.



Abstract

The spread of multidrug-resistant microorganisms globally has created an urgent need for novel therapeutic strategies to combat urinary tract infections (UTIs). Immunomodulatory therapy may provide benefit, as treatment of mice with dexamethasone during acute UTI improved outcome by reducing the development of chronic cystitis, which predisposes to recurrent infection. Here we discovered soluble ...

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