Hubbard-Lucey, Vanessa M. ; Shono, Yusuke ; Maurer, Katie ; West, Mallory L. ; Singer, Natalie V. ; Ziegler, Carly G.K. ; Lezcano, Cecilia ; Motta, Ana Carolina Fragoso 
; Schmid, Karin ; Levi, Samuel M. ; Murphy, George F. ; Liu, Chen ; Winkler, Jeffrey D. ; Amaravadi, Ravi K. ; Rogler, Gerhard ; Dickinson, Anne M. ; Holler, Ernst ; van den Brink, Marcel R.M. ; Cadwell, Ken
; Schmid, Karin ; Levi, Samuel M. ; Murphy, George F. ; Liu, Chen ; Winkler, Jeffrey D. ; Amaravadi, Ravi K. ; Rogler, Gerhard ; Dickinson, Anne M. ; Holler, Ernst ; van den Brink, Marcel R.M. ; Cadwell, Ken 
Abstract
Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. Here we find that Atg16L1 deficiency leads to an exacerbated graft-versus-host disease (GVHD) in a mouse model of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Atg16L1-deficient allo-HSCT ...
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