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Altered mechanobiology of Schlemm’s canal endothelial cells in glaucoma

Overby, Darryl R. ; Zhou, Enhua H. ; Vargas-Pinto, Rocio ; Pedrigi, Ryan M. ; Fuchshofer, Rudolf ; Braakman, Sietse T. ; Gupta, Ritika ; Perkumas, Kristin M. ; Sherwood, Joseph M. ; Vahabikashi, Amir ; Dang, Quynh ; Kim, Jae Hun ; Ethier, C. Ross ; Stamer, W. Daniel ; Fredberg, Jeffrey J. ; Johnson, Mark



Abstract

Increased flow resistance is responsible for the elevated intraocular pressure characteristic of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis that altered biomechanical behavior of Schlemm's canal (SC) cells contributes to this dysfunction. We used atomic force microscopy, optical magnetic twisting cytometry, and a unique cell perfusion apparatus to ...

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