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Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation

Weissinger, E M ; Metzger, J ; Dobbelstein, C ; Wolff, D ; Schleuning, M ; Kuzmina, Z ; Greinix, H ; Dickinson, A M ; Mullen, W ; Kreipe, H ; Hamwi, I ; Morgan, M ; Krons, A ; Tchebotarenko, I ; Ihlenburg-Schwarz, D ; Dammann, E ; Collin, M ; Ehrlich, S ; Diedrich, H ; Stadler, M ; Eder, M ; Holler, E ; Mischak, H ; Krauter, J ; Ganser, A



Abstract

Allogeneic hematopoietic stem cell transplantation is one curative treatment for hematological malignancies, but is compromised by life-threatening complications, such as severe acute graft-versus-host disease (aGvHD). Prediction of severe aGvHD as early as possible is crucial to allow timely initiation of treatment. Here we report on a multicentre validation of an aGvHD-specific urinary ...

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