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Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, Sean P. ; Goh, Christabelle S.M. ; Brown, Sara J. ; Palmer, Colin N.A. ; Porter, Rebecca M. ; Cole, Christian ; Campbell, Linda E. ; Gierlinski, Marek ; Barton, Geoffrey J. ; Schneider, Georg ; Balmain, Allan ; Prescott, Alan R. ; Weidinger, Stephan ; Baurecht, Hansjörg ; Kabesch, Michael ; Gieger, Christian ; Lee, Young-Ae ; Tavendale, Roger ; Mukhopadhyay, Somnath ; Turner, Stephen W. ; Madhok, Vishnu B. ; Sullivan, Frank M. ; Relton, Caroline ; Burn, John ; Meggitt, Simon ; Smith, Catherine H. ; Allen, Michael A. ; Barker, Jonathan N.W. N. ; Reynolds, Nick J. ; Cordell, Heather J. ; Irvine, Alan D. ; McLean, W.H. Irwin ; Sandilands, Aileen ; Fallon, Padraic G.



Abstract

Background: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutation in Flg and also carry an unknown gene, matted, causing a matted hair phenotype. Objective: We ...

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