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Tyrosine specific sequential labeling of proteins

Cserép, Gergely B. ; Herner, András ; Wolfbeis, Otto S. ; Kele, Péter



Abstract

We report (a) on the synthesis of a long-wavelength fluorescent coumarin containing an allyloxy acetate moiety, (b) the synthesis of two linkers containing an allyloxy acetate and an alkyne or azide function, respectively, and (c) the selective modification human serum albumin by a sequential method involving Pd(II) catalyzed modification of the phenolic side chain of tyrosine residues with an ...

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