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Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients

Fischer, Johannes C. ; Niederacher, Dieter ; Topp, Stefan A. ; Honisch, Ellen ; Schumacher, Sarah ; Schmitz, Norma ; Zacarias Föhrding, Luisa ; Vay, Christian ; Hoffmann, Imke ; Kasprowicz, Nikola S. ; Hepp, Philip G. ; Mohrmann, Svjetlana ; Nitz, Ulrike ; Stresemann, Antje ; Krahn, Thomas ; Henze, Tanja ; Griebsch, Evelyn ; Raba, Katharina ; Rox, Jutta M. ; Wenzel, Folker ; Sproll, Christoph ; Janni, Wolfgang ; Fehm, Tanja ; Klein, Christoph A. ; Knoefel, Wolfram Trudo ; Stoecklein, Nikolas H.



Abstract

Circulating tumor cells (CTCs) are promising biomarkers for diagnosis and therapy in systemic cancer. However, their infrequent and unreliable detection, especially in nonmetastatic cancer, currently impedes the clinical use of CTCs. Because leukapheresis (LA) targets peripheral blood mononuclear cells, which have a similar density to CTCs, and usually involves processing the whole circulating ...

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