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The Nlrp3 inflammasome regulates acute graft-versus-host disease

Jankovic, Dragana ; Ganesan, Jayanthi ; Bscheider, Michael ; Stickel, Natalie ; Weber, Felix C. ; Guarda, Greta ; Follo, Marie ; Pfeifer, Dietmar ; Tardivel, Aubry ; Ludigs, Kristina ; Bouazzaoui, Abdellatif ; Kerl, Katrin ; Fischer, Julius C. ; Haas, Tobias ; Schmitt-Gräff, Annette ; Manoharan, Anand ; Müller, Leonard ; Finke, Jürgen ; Martin, Stefan F. ; Gorka, Oliver ; Peschel, Christian ; Ruland, Jürgen ; Idzko, Marco ; Duyster, Justus ; Holler, Ernst ; French, Lars E. ; Poeck, Hendrik ; Contassot, Emmanuel ; Zeiser, Robert



Abstract

The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host disease (GvHD), a severe complication accompanied by high mortality rates. Yet, the molecular mechanisms initiating this disease remain poorly defined. In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid ...

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