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PEG-supported Synthesis of Pyrazole Oligoamides with Peptide β-Sheet Affinity

Černovská, K. ; Kemter, M. ; Gallmeier, H.-C. ; Rzepecki, P. ; Schrader, T. ; König, B.


Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids
or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes
the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties
towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform
and water.

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