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PEG-supported Synthesis of Pyrazole Oligoamides with Peptide β-Sheet Affinity

Černovská, K., Kemter, M., Gallmeier, H.-C., Rzepecki, P., Schrader, T. and König, B. (2004) PEG-supported Synthesis of Pyrazole Oligoamides with Peptide β-Sheet Affinity. Org. Biomol. Chem. 2, 1603 - 1611.

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Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids
or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes
the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties
towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform
and water.

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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:6243
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