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New heterocyclic β-sheet ligands with peptidic recognition elements

Rzepecki, P. ; Gallmeier, H. ; Geib, N. ; König, B. ; Schrader, T.


A detailed and comprehensive overview is presented about the design, modeling, and synthesis, as well as spectroscopic characterization, of a new class of beta-sheet ligands. The characteristic feature of these compounds is a peptidic chimeric structure formed from a specific combination of aminopyrazolecarboxylic acids with naturally occurring alpha-amino acids. These hybrid peptides are ...


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