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Immobilised Zinc (II) Cyclen complexes as catalytic reagents for phosphodiester hydrolysis

Walenzyk, T. ; Koenig, B.


Many hydrolases found in nature have Zn(II) ions at their active site. Artificial hydrolases as alternatives for non-enzymatic hydrolysis were prepared by attaching Zn(II) cyclen complexes with an alcohol pendant to a polymeric support. These modified polymers showed a 104-fold enhanced intrinsic reactivity for the hydrolysis of activated phosphodiesters over the non-catalysed reaction
in solution.

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