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Solid Phase Synthesis of Metal-Complex containing Peptides

Dirscherl, G., Knape, R., Hanson, P. and König, B. (2007) Solid Phase Synthesis of Metal-Complex containing Peptides. Tetrahedron 63, 4918 – 4928.

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We report the synthesis of Fmoc protected single amino acid chelates (SAAC) and their metal complexes. The modified amino acids are suitable for solid-phase peptide synthesis. The use of 4-hydroxymethylbenzoic acid AM (HMBA-AM) resin allows the nucleophilic cleavage of the peptide–metal complexes from the resin without decomplexation.

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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
Keywords:Solid-phase peptide synthesis; Metal complex; Single amino acid chelate
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:6279
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