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Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor

Vomasta, D., Högner, C., Branda, N. R. and König, B. (2008) Regulation of Human Carbonic Anhydrase I (hCAI) Activity by Using a Photochromic Inhibitor. Angew. Chem. 120, pp. 7756-7759.

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Photoswitchable: The activity of a dithienylethene-based human carbonic anhydrase inhibitor (hCAI) can be regulated using light. Converting the flexible, ring-open isomer of the photoswitch into the rigid, ring-closed isomer using UV light reduces the inhibition and increases the activity of hCAI by 50-fold. The inhibitor can be turned back on by using visible light, which has many advantages in biological applications.

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Item type:Article
Additional Information (public):auch erschienen in: Angew. Chem. Int. Ed 47, 7644 - 7647 (2008)
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
18767093PubMed ID
Keywords:carbonic anhydrase · enzyme catalysis · inhibitors · molecular switches · photochromism
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:6298
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