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Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7

Ullmer, C ; Zoffmann, S ; Bohrmann, B ; Matile, H ; Lindemann, L ; Flor, PJ ; Malherbe, P



Zusammenfassung

BACKGROUND AND PURPOSE The mGlu(7) receptors are strategically located at the site of vesicle fusion where they modulate the release of the main excitatory and inhibitory neurotransmitters. Consequently, they are implicated in the underlying pathophysiology of CNS diseases such as epilepsy and stress-related psychiatric disorders. Here, we characterized a selective, potent and functional ...

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