; von Lüttichau, I. ; Klingebiel, T. ; Bader, P. ; Borkhardt, A. ; Laws, H.-J. ; Handgretinger, R. ; Lang, P. ; Schlegel, P. ; Eyrich, M.
; Gruhn, B. ; Ehninger, G. ; Koscielniak, E. ; Klein, C. ; Sykora, K.-W. ; Holler, E. ; Mauz-Körholz, C. ; Woessmann, W. ; Richter, G.H. ; Schmidt, A. ; Peters, C. ; Dirksen, U. ; Jürgens, H. ; Bregni, M. ; Burdach, S. | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Klinische Pädiatrie | ||||
| Publisher: | GEORG THIEME VERLAG KG | ||||
| Place of Publication: | STUTTGART | ||||
| Volume: | 224 | ||||
| Number of Issue or Book Chapter: | 06 | ||||
| Page Range: | pp. 353-358 | ||||
| Date: | 2012 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) | ||||
| Identification Number: |
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| Keywords: | STEM-CELL TRANSPLANTATION; T-CELLS; EUROPEAN INTERGROUP; TUMOR PATIENTS; ASSOCIATION; IMMUNOTHERAPY; EXPRESSION; BONE; RECOGNITION; CHILDREN; Ewing's sarcoma; human leukocyte antigens; risk stratification; biomarkers; immunosurveillance; allogeneic stem cell transplantation | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 63191 |
Abstract
Background: Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls. Patients: HLA types of all German Caucasian patients with advanced ESFT and ...

Abstract
Background: Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls. Patients: HLA types of all German Caucasian patients with advanced ESFT and available HLA-A, -B and -DR data registered in the European Group for Blood and Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA types of healthy German stem cell donors (control group, n=8862 for single HLA frequencies and n=8839 for allele combinations). Study group patients had been immuno-typed due to eligibility for allogeneic stem cell transplantation for high risk of treatment failure, and thus constituted a selected subgroup of ESFT patients. Results: After Bonferroni correction for multiple testing (PC), phenotype frequencies of HLA-A24 remained significantly higher in the study group compared to controls (PC < 0.05). Furthermore, several HLA combinations were significantly more frequent in the study group compared to controls (all PC < 0.05). Conclusion: We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.
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