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Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury

Dhaliwal, Kevin ; Scholefield, Emma ; Ferenbach, David ; Gibbons, Michael ; Duffin, Rodger ; Dorward, David A. ; Morris, Andrew Conway ; Humphries, Duncan ; MacKinnon, Alison ; Wilkinson, Tom S. ; Wallace, William A. H. ; van Rooijen, Nico ; Mack, Matthias ; Rossi, Adriano G. ; Davidson, Donald J. ; Hirani, Nik ; Hughes, Jeremy ; Haslett, Chris ; Simpson, A. John



Abstract

Rationale: Acute lung injury (ALI) is an important cause of morbidity and mortality, with no currently effective pharmacological therapies. Neutrophils have been specifically implicated in the pathogenesis of ALI, and there has been significant research into the mechanisms of early neutrophil recruitment, but those controlling the later phases of neutrophil emigration that characterize disease ...

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