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A lanostane aldehyde from Momordica charantia

Panlilio, Bella G. ; Macabeo, Allan Patrick G. ; Knorn, Matthias ; Kohls, Paul ; Richomme, Pascal ; Kouam, Simeon Fogue ; Gehle, Dietmar ; Krohn, Karsten ; Franzblau, Scott G. ; Zhang, Qingwen ; Aguinaldo, Ma. Alicia M.



Abstract

A new lanostane aldehyde, charantal (1), was isolated from the ethanolic leaf extract of Momordica charantia together with the known compound, 2,4-bis(2-phenylpropan-2-yl)phenol (2). The structure of compound 1 was elucidated by extensive 1D and 2D NMR and MS experiments. Compound 2 displayed a moderately strong antitubercular activity against Mycobacterium tuberculosis H(37)Rv (MIC = 14 mu g/mL) ...

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