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Short‐term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells

Grosse, Jirka ; Wehland, Markus ; Pietsch, Jessica ; Ma, Xiao ; Ulbrich, Claudia ; Schulz, Herbert ; Saar, Katrin ; Hübner, Norbert ; Hauslage, Jens ; Hemmersbach, Ruth ; Braun, Markus ; Loon, Jack ; Vagt, Nicole ; Infanger, Manfred ; Eilles, Christoph ; Egli, Marcel ; Richter, Peter ; Baltz, Theo ; Einspanier, Ralf ; Sharbati, Soroush ; Grimm, Daniela



Abstract

This study focused on the effects of short-term microgravity (22 s) on the gene expression and morphology of endothelial cells (ECs) and evaluated gravisensitive signaling elements. ECs were investigated during four German Space Agency (Deutsches Zentrum fur Luft-und Raumfahrt) parabolic flight campaigns. Hoechst 33342 and acridine orange/ethidium bromide staining showed no signs of cell death in ...

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