Hoetzenecker, Wolfram 
; Echtenacher, Bernd ; Guenova, Emmanuella ; Hoetzenecker, Konrad ; Woelbing, Florian ; Brück, Jürgen ; Teske, Anna ; Valtcheva, Nadejda ; Fuchs, Kerstin ; Kneilling, Manfred ; Park, Ji-Hyeon ; Kim, Kyu-Han ; Kim, Kyu-Won ; Hoffmann, Petra ; Krenn, Claus ; Hai, Tsonwin ; Ghoreschi, Kamran ; Biedermann, Tilo ; Röcken, Martin
; Echtenacher, Bernd ; Guenova, Emmanuella ; Hoetzenecker, Konrad ; Woelbing, Florian ; Brück, Jürgen ; Teske, Anna ; Valtcheva, Nadejda ; Fuchs, Kerstin ; Kneilling, Manfred ; Park, Ji-Hyeon ; Kim, Kyu-Han ; Kim, Kyu-Won ; Hoffmann, Petra ; Krenn, Claus ; Hai, Tsonwin ; Ghoreschi, Kamran ; Biedermann, Tilo ; Röcken, Martin 
Abstract
Sepsis, sepsis-induced hyperinflammation and subsequent sepsis-associated immunosuppression (SAIS) are important causes of death. Here we show in humans that the loss of the major reactive oxygen species (ROS) scavenger, glutathione (GSH), during SAIS directly correlates with an increase in the expression of activating transcription factor 3 (ATF3). In endotoxin-stimulated monocytes, ROS stress ...
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