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Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

Ferrara, James L. M. ; Harris, Andrew C. ; Greenson, Joel K. ; Braun, Thomas M. ; Holler, Ernst ; Teshima, Takanori ; Levine, John E. ; Choi, Sung W. J. ; Huber, Elisabeth ; Landfried, Karin ; Akashi, Koichi ; Vander Lugt, Mark ; Reddy, Pavan ; Chin, Alice ; Zhang, Qing ; Hanash, Samir ; Paczesny, Sophie



Abstract

There are no plasma biomarkers specific for GVHD of the gastrointestinal (GI) tract, the GVHD target organ most associated with nonrelapse mortality (NRM) following hematopoietic cell transplantation (HCT). Using an unbiased, large-scale, quantitative proteomic discovery approach to identify candidate biomarkers that were increased in plasma from HCT patients with GI GVHD, 74 proteins were ...

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