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Sox10 is required for Schwann‐cell homeostasis and myelin maintenance in the adult peripheral nerve

Bremer, Magdalena ; Fröb, Franziska ; Kichko, Tatjana ; Reeh, Peter ; Tamm, Ernst R. ; Suter, Ueli ; Wegner, Michael



Zusammenfassung

The transcription factor Sox10 functions during multiple consecutive stages of Schwann-cell development in the peripheral nervous system (PNS). Although Sox10 continues to be expressed in mature Schwann cells of the adult peripheral nerve, it is currently unclear whether it is still functional. Here, we used a genetic strategy to selectively delete Sox10 in glia of adult mice in a ...

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