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Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial

Diener, Markus K ; Seiler, Christoph M ; Rossion, Inga ; Kleeff, Jörg ; Glanemann, Matthias ; Butturini, Giovanni ; Tomazic, Ales ; Bruns, Christiane J ; Busch, Olivier RC ; Farkas, Stefan ; Belyaev, Orlin ; Neoptolemos, John P ; Halloran, Christopher ; Keck, Tobias ; Niedergethmann, Marco ; Gellert, Klaus ; Witzigmann, Helmut ; Kollmar, Otto ; Langer, Peter ; Steger, Ulrich ; Neudecker, Jens ; Berrevoet, Frederik ; Ganzera, Silke ; Heiss, Markus M ; Luntz, Steffen P ; Bruckner, Thomas ; Kieser, Meinhard ; Büchler, Markus W



Abstract

Background The ideal closure technique of the pancreas after distal pancreatectomy is unknown. We postulated that standardised closure with a stapler device would prevent pancreatic fistula more effectively than would a hand-sewn closure of the remnant. Methods This multicentre, randomised, controlled, parallel group-sequential superiority trial was done in 21 European hospitals. Patients with ...

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