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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | NATURE PUBLISHING GROUP | ||||
Place of Publication: | NEW YORK | ||||
Volume: | 43 | ||||
Number of Issue or Book Chapter: | 4 | ||||
Page Range: | pp. 333-338 | ||||
Date: | 2011 | ||||
Institutions: | Medicine > Lehrstuhl für Innere Medizin II | ||||
Identification Number: |
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Keywords: | GENOME-WIDE ASSOCIATION; MYOCARDIAL-INFARCTION; HEART-DISEASE; VARIANTS; DESIGN; RISK; EXPRESSION; GENETICS; ATHEROSCLEROSIS; POLYMORPHISMS; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 65081 |
Abstract
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 ...

Abstract
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
Metadata last modified: 25 Jun 2025 06:11