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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Schunkert, Heribert ; König, Inke R. ; Kathiresan, Sekar ; Reilly, Muredach P. ; Assimes, Themistocles L. ; Holm, Hilma ; Preuss, Michael ; Stewart, Alexandre F. R. ; Barbalic, Maja ; Gieger, Christian ; Absher, Devin ; Aherrahrou, Zouhair ; Allayee, Hooman ; Altshuler, David ; Anand, Sonia S. ; Andersen, Karl ; Anderson, Jeffrey L. ; Ardissino, Diego ; Ball, Stephen G. ; Balmforth, Anthony J. ; Barnes, Timothy A. ; Becker, Diane M. ; Becker, Lewis C. ; Berger, Klaus ; Bis, Joshua C. ; Boekholdt, S.Matthijs ; Boerwinkle, Eric ; Braund, Peter S. ; Brown, Morris J. ; Burnett, Mary Susan ; Buysschaert, Ian ; Carlquist, John F. ; Chen, Li ; Cichon, Sven ; Codd, Veryan ; Davies, Robert W. ; Dedoussis, George ; Dehghan, Abbas ; Demissie, Serkalem ; Devaney, Joseph M. ; Diemert, Patrick ; Do, Ron ; Doering, Angela ; Eifert, Sandra ; Mokhtari, Nour Eddine El ; Ellis, Stephen G. ; Elosua, Roberto ; Engert, James C. ; Epstein, Stephen E. ; de Faire, Ulf ; Fischer, Marcus ; Folsom, Aaron R. ; Freyer, Jennifer ; Gigante, Bruna ; Girelli, Domenico ; Gretarsdottir, Solveig ; Gudnason, Vilmundur ; Gulcher, Jeffrey R. ; Halperin, Eran ; Hammond, Naomi ; Hazen, Stanley L. ; Hofman, Albert ; Horne, Benjamin D. ; Illig, Thomas ; Iribarren, Carlos ; Jones, Gregory T. ; Jukema, J. Wouter ; Kaiser, Michael A. ; Kaplan, Lee M. ; Kastelein, John J. P. ; Khaw, Kay-Tee ; Knowles, Joshua W. ; Kolovou, Genovefa ; Kong, Augustine ; Laaksonen, Reijo ; Lambrechts, Diether ; Leander, Karin ; Lettre, Guillaume ; Li, Mingyao ; Lieb, Wolfgang ; Loley, Christina ; Lotery, Andrew J. ; Mannucci, Pier M. ; Maouche, Seraya ; Martinelli, Nicola ; McKeown, Pascal P. ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Merlini, Pier Angelica ; Mooser, Vincent ; Morgan, Thomas ; Mühleisen, Thomas W. ; Muhlestein, Joseph B. ; Münzel, Thomas ; Musunuru, Kiran ; Nahrstaedt, Janja ; Nelson, Christopher P. ; Nöthen, Markus M. ; Olivieri, Oliviero ; Patel, Riyaz S. ; Patterson, Chris C. ; Peters, Annette ; Peyvandi, Flora ; Qu, Liming ; Quyyumi, Arshed A. ; Rader, Daniel J. ; Rallidis, Loukianos S. ; Rice, Catherine ; Rosendaal, Frits R. ; Rubin, Diana ; Salomaa, Veikko ; Sampietro, M. Lourdes ; Sandhu, Manj S. ; Schadt, Eric ; Schäfer, Arne ; Schillert, Arne ; Schreiber, Stefan ; Schrezenmeir, Jürgen ; Schwartz, Stephen M. ; Siscovick, David S. ; Sivananthan, Mohan ; Sivapalaratnam, Suthesh ; Smith, Albert ; Smith, Tamara B. ; Snoep, Jaapjan D. ; Soranzo, Nicole ; Spertus, John A. ; Stark, Klaus ; Stirrups, Kathy ; Stoll, Monika ; Tang, W. H. Wilson ; Tennstedt, Stephanie ; Thorgeirsson, Gudmundur ; Thorleifsson, Gudmar ; Tomaszewski, Maciej ; Uitterlinden, Andre G. ; van Rij, Andre M. ; Voight, Benjamin F. ; Wareham, Nick J. ; Wells, George A. ; Wichmann, H.-Erich ; Wild, Philipp S. ; Willenborg, Christina ; Witteman, Jaqueline C. M. ; Wright, Benjamin J. ; Ye, Shu ; Zeller, Tanja ; Ziegler, Andreas ; Cambien, Francois ; Goodall, Alison H. ; Cupples, L. Adrienne ; Quertermous, Thomas ; März, Winfried ; Hengstenberg, Christian ; Blankenberg, Stefan ; Ouwehand, Willem H. ; Hall, Alistair S. ; Deloukas, Panos ; Thompson, John R. ; Stefansson, Kari ; Roberts, Robert ; Thorsteinsdottir, Unnur ; O'Donnell, Christopher J. ; McPherson, Ruth ; Erdmann, Jeanette



Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 ...

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