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Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

Pichler, Irene ; Minelli, Cosetta ; Sanna, Serena ; Tanaka, Toshiko ; Schwienbacher, Christine ; Naitza, Silvia ; Porcu, Eleonora ; Pattaro, Cristian ; Busonero, Fabio ; Zanon, Alessandra ; Maschio, Andrea ; Melville, Scott A. ; Grazia Piras, Maria ; Longo, Dan L. ; Guralnik, Jack ; Hernandez, Dena ; Bandinelli, Stefania ; Aigner, Elmar ; Murphy, Anthony T. ; Wroblewski, Victor ; Marroni, Fabio ; Theurl, Igor ; Gnewuch, Carsten ; Schadt, Eric ; Mitterer, Manfred ; Schlessinger, David ; Ferrucci, Luigi ; Witcher, Derrick R. ; Hicks, Andrew A. ; Weiss, Günter ; Uda, Manuela ; Pramstaller, Peter P.



Abstract

The genetic determinants of variation in iron status are actively sought, but remain incompletely understood. Meta-analysis of two genome-wide association (GWA) studies and replication in three independent cohorts was performed to identify genetic loci associated in the general population with serum levels of iron and markers of iron status, including transferrin, ferritin, soluble transferrin ...

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