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Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome

Armache, Jean-Paul ; Jarasch, Alexander ; Anger, Andreas M. ; Villa, Elizabeth ; Becker, Thomas ; Bhushan, Shashi ; Jossinet, Fabrice ; Habeck, Michael ; Dindar, Gülcin ; Franckenberg, Sibylle ; Marquez, Viter ; Mielke, Thorsten ; Thomm, Michael ; Berninghausen, Otto ; Beatrix, Birgitta ; Söding, Johannes ; Westhof, Eric ; Wilson, Daniel N. ; Beckmann, Roland



Abstract

Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectron microscopy reconstructions of a translating plant (Triticum aestivum) 80S ...

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