| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Talanta | ||||
| Publisher: | ELSEVIER SCIENCE BV | ||||
| Place of Publication: | AMSTERDAM | ||||
| Volume: | 82 | ||||
| Number of Issue or Book Chapter: | 1 | ||||
| Page Range: | pp. 38-43 | ||||
| Date: | 2010 | ||||
| Institutions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik) | ||||
| Identification Number: |
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| Keywords: | HPLC-ICP-MS; GAS-CHROMATOGRAPHY; CONTAINING LIPIDS; ORGANIC COMPOUNDS; MARINE; SPECIATION; WATER; ARSENOLIPIDS; OIL; IDENTIFICATION; Speciation; Arsenolipids; Hyphenated techniques; Gas chromatography; TOF-MS; Cod liver tissue | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 66002 |
Web of ScienceAbstract
Arsenic is a metalloid well known to be potentially toxic depending of its species. Lipid-soluble arsenicals (arsenolipids) are present in a wide range of biological samples in which they could play a role in the biosynthesis of organoarsenic compounds from inorganic arsenic compounds. Arsenolipids have recently attracted considerable interest. In order to gain deeper insights into the impact of ...
Abstract
Arsenic is a metalloid well known to be potentially toxic depending of its species. Lipid-soluble arsenicals (arsenolipids) are present in a wide range of biological samples in which they could play a role in the biosynthesis of organoarsenic compounds from inorganic arsenic compounds. Arsenolipids have recently attracted considerable interest. In order to gain deeper insights into the impact of arsenolipids new analytical approaches for reliable determination of this class of arsenic-containing hydrocarbons in various matrices are needed. High concentrations of arsenolipids were found in seafood which served as sample material in this study. We report the investigation of three arsenolipids found in canned cod liver from which they were extracted and purified by solid phase extraction (SPE) using a silica gel column and ethyl acetate/methanol as eluent. Analytical studies were conducted by means of gas chromatography coupled with ICP-MS, MIP-AES and EI-qMS and by TOF-MS. The results obtained by GC-ICP-MS and GC-MIP-AES showed the existence of numerous arsenic compounds in the SPE fractions collected. Three major peaks were found within a retention time window between Wand 25 min. The presence of arsenic compounds in the fish tissue could be confirmed using GC-EI-qMS analysis. Corresponding information of the molecular weights of the major arsenic species were provided by TOF-MS which allows highly accurate mass determinations. The results showed the presence of the arsenic-containing hydrocarbons with the following molecular formulas: C17H37AsO (calculated for [M+H](+) 333.2133; found 333.2136; Delta m = 0.90 ppm); C19H41AsO (calculated for [M+H](+) 361.2446; found 361.2446; Delta m = 0.00 ppm): C23H37AsO (calculated for [M+H](+) 405.2133; found 405.2145; Delta m = 2.96 ppm). Suggestions for the corresponding structures are discussed. (C) 2010 Elsevier B.V. All rights reserved.
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